antibodies - 2025 ACF Fall

Tossup

One of these molecules is chemically linked to a cytotoxic payload in an ADC, a form of targeted cancer therapy. (10[2]-5[1])HAT (10[1])medium is used to incubate hybridomas in a technique for producing large (10[1]-5[1])amounts of one type (10[2])of these molecules. (10[5])These molecules’ hinge regions connect their Fab (10[5]-5[1])(“F-A-B”) and Fc (10[3])(“F-C”) regions. (10[8])The diversity of certain receptors and these molecules (10[1]-5[1])is facilitated (10[1])through V(D)J (10[1])recombination. (10[7])A type of these proteins (10[1])that (10[1])only recognizes (10[1])a single target (10[2]-5[1])is called (10[4]-5[1])“monoclonal.” (10[8]-5[3])These (10[3])proteins (10[5]-5[1])can (10[3])class-switch (10[10])between their (10[1])five isotypes (10[2])and consist of two heavy chains and two light chains. (10[4])For 10 (-5[1])points, B cells (10[1])produce (-5[1])what (10[1])Y-shaped (10[2])proteins (10[5])that (10[2])bind to (10[1])antigens? (10[3]0[1]-5[1])■END■ (10[17]0[6])

ANSWER: antibodies [or antibody; or immunoglobulins; accept monoclonal antibodies or mAbs; accept Igs; accept antibody-drug conjugates] (The receptors in the fourth line are T-cell receptors.)

<Editors, Biology>

= Average correct buzz position

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Buzzes

Player	Team	Opponent	Position	Value
Eric Morshed	Johns Hopkins	Stony Brook	19	10
Matthew Kohn	Williams A	Dartmouth A	19	10
Jeremy Scurlock	Chipola College	Georgia Tech A	19	-5
Kevin Hendargo	UCSD A	UCLA D	20	10
Aaryan Sumesh	Berkeley Archer Queen	Stanford B	32	-5
Ilyas Choukri	Virginia Tech A	NCSU A	32	10
Rohit Chintala	Maryland B	NYU A	36	10
Eric Yang	Purdue A	Illinois Blue	36	10
Will Marcotte	Toronto D	Toronto C	39	10
Jeremy Kim	Toronto F	Toronto I	39	10
Sarah Dong	Michigan A	Michigan State A	39	10
Yoyo Liu	British Columbia C	British Columbia A	39	10
Judah Solomon	Imperial D	Bristol	39	10
Ethan Ririe	UCSD B	Claremont A	46	10
Anna Liao	Michigan B	CWRU B	46	10
Asish Madarapu	UNC D	UNC B	46	10
Emily Kadolph	Virginia Tech B	William & Mary A	46	10
Aiden Shields	Clemson A	Vanderbilt A	46	-5
Bethany Howard	Imperial A	Birmingham	46	10
Nick Machin	UCLA A	Claremont C	48	10
Alden Thompson	Carleton A	Ottawa C	48	10
Sai Subramanian	CWRU A	Louisville A	48	10
Ishan Pachauri	UCLA C	Claremont B	49	10
James Xiao	Toronto A	Toronto B	49	10
Leonard Castine	Penn	George Mason B	49	10
David Black	Illinois Champaign	Illinois Orange	49	10
Surya Dinesh	MIT A	Williams B	49	10
Yasmin Campbell	Cambridge B	Southampton	49	10
Saleena Livera	Imperial B	Cambridge D	49	10
Sia Kalia	Warwick	Cambridge E	49	10
Arjun Saulnier	CWRU C	Kentucky	57	-5
Advaith Jagannath	Cambridge C	LSE	57	10
Charlie Ruff	McGill A	Ottawa A	59	10
Michael Xu	McMaster B	Waterloo B	61	10
Joseph Strom	Louisville B	CWRU D	62	10
Pratham Bhanushali	WVU B	Louisville C	62	10
Liam Rojas	Virginia A	UNC A	62	10
Fern Fang	VCU A	UNC C	62	10
Xavier Bornhorst	Maryland A	Maryland C	62	10
Grace Early	Iowa A	Rose-Hulman A	62	10
Beckett Pursey	Purdue B	WashU Grizzlers	62	10
Brayden Zhang	Vanderbilt B	Auburn C	67	10
Carly Hemani	JMU A	Liberty A	68	10
Saswat Sasha Tripathi	Chicago A	WashU Grolars	70	10
Jacob Goodson	Ohio State A	Ohio State B	73	-5
Misty Chen	Purdue C	Indiana A	73	10
Daniel Lu	Washington Pink	Texas	73	10
Susanna Liao	Waterloo A	McMaster A	75	10
Bonham Buchannon	Louisville D	Pittsburgh	75	-5
Matthew Bucek	George Mason A	Rutgers A	75	10
Cooper Morris	Columbia B	Rutgers C	75	10
Harri Slaughter	Cardiff	Cambridge A	75	10
Galen Mueller	McGill B	Ottawa D	76	10
Malcolm Meyn	McGill C	Ottawa B	76	10
Lucas Hall	Waterloo C	Guelph A	76	-5
Reed Sexton	Michigan C	Michigan State B	76	10
Jun Chen	George Mason C	Vassar B	76	-5
Dustin Sanders	Chicago B	Illinois Canada	76	10
Andrew Park	Harvard	MIT B	76	-5
Caleb Slusher	South Carolina A	Georgia Tech C	76	10
Samarth Prajapati	Georgia Tech E	Auburn B	76	10
Laura Bullock	Sheffield A	Edinburgh C	76	10
Eli O'Sick Johnson	Binghamton C	Cornell C	76	10
Johnathan Ahdout	Princeton	Rutgers B	77	10
Eames Weeks	Brown A	Tufts A	77	10
Liam Markland	Alberta A	Washington Chum	77	10
Magnolia Schnirman Barría	NYU B	Columbia A	78	10
Alex Dzurick	William Woods University A	Illinois Urbana	78	10
Alan Fan	Washington Steelhead	Arizona State A	78	-5
Jacie Bradley	Clemson C	Tennessee B	78	10
Benjamin Turner	York	Durham D	78	10
Alex Forman	Cornell D	RIT A	78	10
Brendan Bridle	Queen's A	Toronto H	79	10
Nishad Joshi	Kentucky	CWRU C	79	10
Yvonne Pan	Amherst B	Boston College B	79	10
Steven McPhillimey	Lehigh A	Lehigh B	80	10
Drew Wetterlind	Iowa State	Wisconsin A	80	10
Anthony Xu	Amherst A	Vermont B	80	10
Nikhil Nair	Boston University B	Tufts C	80	10
Annabelle Koopmans	Washington Atlantic	Boise State	80	10
Henry Rutherford-Braun	British Columbia B	Washington Sockeye	80	10
Daniel Chen	Emory A	Auburn A	80	10
Isy Simpkins	Durham B	Edinburgh D	80	10
Aaron Wang	Cornell A	Binghamton A	80	10
Ben Gardberg	Cornell B	Rochester	80	10
Ryan Zhang	Washington State	Arizona State B	82	10
Valentina Chamandy	McGill E	Carleton B	84	10
Haylee Weisner	Washington Masu	Washington Chinook	84	10
Danny Han	Stanford B	Berkeley Archer Queen	94	10
Cole Hennessy	UCF A	Florida A	94	10
John Shelly	Rowan	NYU C	94	10
Steven Huang	Boston College A	Brown B	94	10
Andrew Nucci	UCLA B	UC Santa Barbara	96	-5
Nitinkisor Rajesh Kumar	Edinburgh B	Edinburgh A	99	10
Eric Cameron	Michigan State C	Michigan State D	100	-5
John Shelley	Clemson B	Georgia Tech D	101	10
Scott Hyde	Georgia Tech B	Tennessee Tech	102	10
Isaiah Schmid	Binghamton B	ESF	102	10
Advai Srinivasan	UC Irvine	USC B	103	10
Jonathan Schnipper	Brandeis Mozart	Dartmouth B	103	10
Kaushik Jayaprabha	Dartmouth C	Brandeis Beethoven	103	10
Martin Brandenburg	Georgia A	Georgia Tech F	103	10
Andreas Ktori	Durham A	Sheffield B	103	10
Joseph Wang	UCLA E	UCLA F	104	10
Agatha Dahle	WVU A	Ohio State D	104	10
Lola Maas	Washington Coho	Alberta B	106	10
Levan Tsiskarisvili	JMU B	NCSU B	107	-5
Walter Carson	NCSU B	JMU B	107	0
Caleigh Greene	Tusculum A	Liberty B	107	10
Mahathi Veluri	UConn A	Brandeis Bach	107	10
Ethan Miniard	Montevallo	Sewanne	107	10
Winston Zuo	UC Santa Barbara	UCLA B	108	0
Ibraheem Alkrahgholy	Guelph A	Waterloo C	108	10
Adithya Parat	McMaster C	Brock A	108	10
Andrew Lin	Toronto G	Toronto E	108	0
Platon Gorokhov	Toronto E	Toronto G	108	0
Jack Rabaut	Michigan D	Ohio State C	108	10
Elena Yarrington	Michigan State D	Michigan State C	108	10
Andrew McKenzie	Ohio State B	Ohio State A	108	10
Zac Stapler	Pittsburgh	Louisville D	108	10
David Ropp	Duke A	William & Mary C	108	0
Cara Leonard	William & Mary C	Duke A	108	10
Alex Wong	Rutgers D	Vassar A	108	10
Andrew Sklar	Vassar B	George Mason C	108	10
Emily Justak	Indiana B	Purdue D	108	10
Kyle Hart	MIT B	Harvard	108	0
Cy Stavros	Vermont A	Boston University A	108	10
Rae Meyers	Arizona State A	Washington Steelhead	108	10
Jackson McDonald	Alabama A	Tennessee A	108	10
Bharath Ram	Georgia Tech A	Chipola College	108	10
Towery McNeil	Mississippi State A	Vanderbilt C	108	0
Edward Zhang	Vanderbilt C	Mississippi State A	108	10
Darren Kellis	Vanderbilt A	Clemson A	108	10
Will Barton	Imperial C	Oxford	108	10

Summary

Tournament	Edition	TUH	Conv. %	Neg %	Average Buzz
UK (North)	UK	5	100%	0%	87.20
UK (South)	UK	8	100%	0%	59.00
Northern California	US	1	100%	100%	94.00
Southern California	US	7	86%	14%	61.67
Eastern Canada (1)	US	5	100%	0%	68.60
Eastern Canada (2)	US	9	89%	11%	69.75
Florida	US	1	100%	0%	94.00
Great Lakes	US	12	100%	33%	79.00
Lower Mid-Atlantic	US	9	89%	11%	66.38
Upper Mid-Atlantic	US	12	100%	8%	71.75
Midwest	US	9	100%	0%	68.22
North	US	1	100%	0%	80.00
Northeast	US	12	92%	8%	81.73
Pacific	US	9	100%	11%	81.00
Southeast	US	13	100%	15%	94.00
Upstate NY	US	5	100%	0%	83.20