Round 10: Tossup 7

One of these molecules is chemically linked to a cytotoxic payload in an ADC, a form of targeted cancer therapy. HAT (10[1])medium is used to incubate hybridomas in a technique for producing large amounts of one type of these molecules. These molecules’ hinge regions connect their Fab (10[1])(“F-A-B”) and Fc (10[1])(“F-C”) regions. (10[1])The diversity of certain receptors and these molecules is facilitated through V(D)J recombination. A type of these proteins that only recognizes a single target is called “monoclonal.” These proteins can class-switch between their five isotypes and consist of two heavy chains and two light chains. For 10 (-5[1])points, B cells produce what Y-shaped proteins (10[1])that (10[1])bind to antigens? ■END■ (0[1])

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