Tossup

One of these molecules is chemically linked to a cytotoxic payload in an ADC, a form of targeted cancer therapy. HAT (10[1])medium is used to incubate hybridomas in a technique for producing large amounts of one type of these molecules. These molecules’ hinge regions connect their Fab (10[1])(“F-A-B”) and Fc (10[1])(“F-C”) regions. (10[1])The diversity of certain receptors and these molecules is facilitated through V(D)J recombination. A type of these proteins that only recognizes a single target is called “monoclonal.” These proteins can class-switch between their five isotypes and consist of two heavy chains and two light chains. For 10 (-5[1])points, B cells produce what Y-shaped proteins (10[1])that (10[1])bind to antigens? ■END■ (0[1])

ANSWER: antibodies [or antibody; or immunoglobulins; accept monoclonal antibodies or mAbs; accept Igs; accept antibody-drug conjugates] (The receptors in the fourth line are T-cell receptors.)
<Editors, Biology>
= Average correct buzz position

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Buzzes


Summary

TournamentEditionTUHConv. %Neg %Average Buzz
UK (North)UK5100%0%87.20
UK (South)UK8100%0%59.00
Northern CaliforniaUS1100%100%94.00
Southern CaliforniaUS786%14%61.67
Eastern Canada (1)US5100%0%68.60
Eastern Canada (2)US989%11%69.75
FloridaUS1100%0%94.00
Great LakesUS12100%33%79.00
Lower Mid-AtlanticUS989%11%66.38
Upper Mid-AtlanticUS12100%8%71.75
MidwestUS9100%0%68.22
NorthUS1100%0%80.00
NortheastUS1292%8%81.73
PacificUS9100%11%81.00
SoutheastUS13100%15%94.00
Upstate NYUS5100%0%83.20