Round 10: Tossup 7

One of these molecules is chemically linked to a cytotoxic payload in an ADC, a form of targeted cancer therapy. HAT medium is used to incubate hybridomas in a technique for producing large amounts of one type of these molecules. These molecules’ hinge regions connect their Fab (“F-A-B”) and Fc (“F-C”) regions. The diversity of certain receptors and these molecules is facilitated through V(D)J recombination. A type of these proteins that only recognizes a single target is called “monoclonal.” (10[1])These proteins (10[1])can class-switch (10[2])between their five isotypes and consist of two heavy chains and two light chains. For 10 points, B cells produce what Y-shaped (10[1])proteins that bind to antigens? ■END■

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