doses - 2025 ACF Fall

Tossup

Note to moderator: read the answerline carefully. Note to players: specific term required. An effect is still elicited when this quantity is zero in the E-max model. Curves that show the “response” to this quantity can be fitted to the Hill equation and are sigmoidal in shape. This quantity is measured in grams per cubic meter or grams (-5[1])per (-5[1])kilogram of (-5[1])body (-5[1])weight (-5[4])depending on the (-5[1])route of (-5[1])application. (10[1]-5[2])The (10[1])therapeutic (10[1])index (10[1])is equal (10[1]-5[1])to the ratio (10[1])of (-5[1])two of these (10[1])quantities. (10[5]-5[2])This quantity’s efficacy is related to concentration (10[1])and (10[1])duration of exposure. (10[2]-5[1])A form of this (10[1])quantity (10[1])required (10[1])to kill (10[1]-5[1])half (10[3])of all (10[1])test (10[1])subjects (10[3])is (10[1]-5[1])reported (10[3]-5[3])as (10[1])the (-5[1])LD50, (10[9]-5[2])or this (-5[1])quantity’s (10[3])“lethal” (10[3]-5[2])form. (10[8]-5[4])For 10 points, (10[5]-5[1])what quantity (10[3])equals (10[1])the amount (10[1]-5[1])of a drug (10[1])administered (10[8]-5[1])to (10[2])a patient? (10[8])■END■ (10[40]0[3])

ANSWER: doses [accept dosages; accept median lethal dose or semilethal dose or lethal dose, 50 percent or median effective dose; or median toxic dose; accept dose-response curves or dose-response relationships; prompt on stimulus response curve or stimulus response function by asking “what quantity acts as the stimulus?”; prompt on volume by asking “what is the more specific term?”; prompt on ED50 or TD50; prompt on descriptions of the amount of a drug or pharmaceutical until read by asking “what is the more specific term?”; prompt on LD50 or LC50 or LCt50 until “LD50” is read; prompt on concentration or lethal concentration or effective concentration until read by asking “what is the more specific term?”; prompt on exposure until read by asking “what is the more specific term?”]

<Editors, Chemistry>

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Buzzes

Player	Team	Opponent	Position	Value
Ben Weng	Macalester	Wisconsin A	57	-5
Charlie Rickards	Ottawa C	Carleton A	58	-5
Anirudh Terdal	LSE	Warwick	60	-5
Noah Trochessett	Florida B	UCF A	61	-5
Aaryan Sumesh	Berkeley Archer Queen	Berkeley Boss Bandit	62	-5
Hansen Jin	Berkeley Skeleton King	Stanford A	62	-5
Miles Phillips	Florida Tech B	Florida State A	62	-5
Arthur Zhang	Purdue C	Illinois Orange	62	-5
Rohan Soni	UCLA F	UC Santa Barbara	65	-5
Advai Srinivasan	UC Irvine	UCLA E	67	-5
Kevin Yang	Illinois Blue	Illinois Canada	68	10
Anya Srinivasan	Washington Atlantic	British Columbia A	68	-5
Michael Shipman	Cambridge D	Imperial A	68	-5
Charlie Ruff	McGill A	Ottawa A	69	10
Nicholas Decker	George Mason A	Rutgers D	70	10
Pace Klein	CWRU B	CWRU C	71	10
Aditya Koushik	Stanford B	Berkeley Mighty Miner	73	-5
Andreas Ktori	Durham A	Durham B	73	10
Annika Larson	Claremont A	UCLA B	76	10
William Henley	Illinois Champaign	William Woods University A	77	-5
Jesse Mindel	NCSU A	Virginia Tech B	80	10
Platon Gorokhov	Toronto E	Waterloo B	81	10
Matthew Stall	CWRU D	Michigan State A	81	-5
Eric Morshed	Johns Hopkins	Columbia A	81	10
Luke Sauer	Michigan Tech	Minnesota	81	10
Coy Mier	Auburn B	Tennessee Tech	81	-5
Daniel Chen	Emory A	Georgia Tech F	81	10
Aidan Keenan	Rochester	RIT A	81	10
Tianyi Zheng	UCSD B	UCLA D	88	10
Valentina Chamandy	McGill E	Carleton B	89	10
Reed Sexton	Michigan C	Louisville C	92	10
Beckett Pursey	Purdue B	Indiana A	92	10
Madeline Painter	Georgia Tech D	Sewanne	92	-5
Meredie Cohen	William & Mary A	UNC A	96	10
Jason Lee	Rutgers A	Vassar A	97	10
Jonathan Ho	Alberta B	Washington Masu	98	10
Yishak Kelkay	ERAU Daytona A	South Florida A	100	-5
Ryan Gomes	Florida Tech A	Florida A	100	10
David Yuan	Berkeley Little Prince	UCSC	101	10
Sarah Dong	Michigan A	Michigan State C	101	10
Ben Mowery	Vermont A	Boston College B	101	10
Towery McNeil	Mississippi State A	Vanderbilt C	103	10
Victor Xu	Toronto B	Toronto D	104	10
Xavier Bornhorst	Maryland A	Princeton	105	10
Liam Markland	Alberta A	British Columbia B	105	10
Wesley Stine	Clemson A	Alabama A	105	10
Saswat Sasha Tripathi	Chicago A	Indiana B	106	-5
Oliver West	Cambridge B	Imperial C	106	10
Malcolm Meyn	McGill C	McGill B	107	10
Brendan Bridle	Queen's A	McMaster C	107	10
Jeremy Kim	Toronto F	Toronto H	107	-5
Elizabeth Ziberman	Stony Brook	George Mason C	107	-5
Cooper Morris	Columbia B	Rowan	107	-5
Vikram Rajmohan	Amherst A	Williams B	107	10
Emerson Patmore	Georgia Tech C	Tennessee A	108	10
Nick Machin	UCLA A	UCSD A	109	-5
Brennan Davis	Louisville B	Louisville A	110	10
Andrew McKenzie	Ohio State B	Pittsburgh	110	-5
Jacob Goodson	Ohio State A	WVU B	110	10
Ilyas Choukri	Virginia Tech A	Virginia A	110	10
Cara Leonard	William & Mary C	JMU A	110	10
Kelvin Ni	NYU A	George Mason B	110	10
Tishe Sonuga	Chicago B	WashU Grizzlers	110	-5
Ayaan Jajodia	Dartmouth B	Boston University A	110	10
Yoyo Liu	British Columbia C	Arizona State A	110	10
Pen Hughes	Edinburgh C	Sheffield B	110	10
Ariyan Miah	Binghamton B	Cornell B	110	10
Elliott Gomes	Dartmouth A	Amherst B	112	-5
Bonham Buchannon	Louisville D	Ohio State D	113	10
Thomas Newill	Tufts C	Brown A	113	10
Benjamin Turner	York	Edinburgh B	113	10
Jackson Crickard	Claremont B	USC A	114	-5
John Rootham	Ottawa D	Ottawa B	114	10
Lucas Hall	Waterloo C	Toronto G	114	10
Austin Tran	Rose-Hulman A	WashU Grolars	114	10
Indigo Khanna	Vermont B	Brandeis Mozart	114	-5
Indiana Gee	Toronto I	Brock A	115	10
Seth Allen	McMaster A	Toronto A	115	10
Deepanshi Matai	Toronto C	Waterloo A	115	-5
Andy Campbell	VCU A	Virginia Tech C	115	10
Elias Lowrey	Lehigh B	NYU C	115	-5
Andrew Sklar	Vassar B	Penn	115	10
Gabe Rosen-Turits	NYU B	Rutgers C	115	10
Connor King	St. Thomas	Iowa State	115	10
Matthew Kohn	Williams A	Southern Connecticut State University A	115	-5
Eleanor Arron	Williams C	Brandeis Bach	115	10
James Haddix	Washington State	Washington Pink	115	10
Nitish Sudhakar	Georgia Tech A	South Carolina A	115	-5
Noah Fine	UNC D	UNC C	118	10
Alex Grigoriades	Lehigh A	Maryland C	118	-5
Justin Gilbert	Auburn C	Vanderbilt B	118	10
Andrew Heller	Georgia Tech E	Georgia A	118	10
James Headon	Edinburgh A	Durham C	118	10
Alex Forman	Cornell D	Binghamton A	118	10
Sri Lnu	Clemson B	Tennessee B	120	10
Doug Frederick	Auburn A	Georgia Tech B	120	10
Derek Li	Cornell A	Cornell C	120	10
Kevin Liu	Texas	Arizona State B	121	10
Angelo Pan	CWRU A	Michigan D	123	-5
Nishad Joshi	Kentucky	Michigan State D	123	10
James Stadler	Imperial B	Imperial D	126	10
Sarah Silverman	Claremont C	USC B	127	10
Becca Wu	JMU B	Liberty C	127	10
Alex Emmert	Maryland B	Rutgers B	127	10
Alex Dzurick	William Woods University A	Illinois Champaign	127	10
Hanson Hunynh	Boston University B	Brandeis Beethoven	127	10
Aman Sreshta	Clemson C	Montevallo	127	10
Jeremy Scurlock	Chipola College	Vanderbilt A	127	10
Rob Morris	Durham D	Sheffield A	127	10
Aeron Wheel	Cardiff	Bristol	127	-5
Alex Hestermann	Washington Sockeye	Boise State	128	10
Dan Millington	Birmingham	Cambridge C	128	10
Vijay Hans	Berkeley Boss Bandit	Berkeley Archer Queen	130	10
Alden Thompson	Carleton A	Ottawa C	130	10
Michael Xu	McMaster B	Guelph A	130	10
Sicheng Jiang	Toronto H	Toronto F	130	10
Miles Spieler	Ohio State C	Michigan State B	130	10
Owen Ashbrook	Iowa A	Illinois Urbana	130	10
Steven Huang	Boston College A	Tufts B	130	10
Brendan Liaw	British Columbia A	Washington Atlantic	130	10
Ty Brennan	Berkeley Mighty Miner	Stanford B	131	10
Ritisha Dey	Stanford A	Berkeley Skeleton King	131	10
Joseph Wang	UCLA E	UC Irvine	131	10
March Delfin	UCSD A	UCLA A	131	10
Winston Zuo	UC Santa Barbara	UCLA F	131	10
Chris Chang	USC A	Claremont B	131	10
Dawson Teu	Waterloo A	Toronto C	131	10
Addison Wiggins	South Florida A	ERAU Daytona A	131	10
AnnaMaria Donnelly	UCF A	Florida B	131	10
Juan Landaeta	Florida State A	Florida Tech B	131	10
Gary Wang	Michigan D	CWRU A	131	10
Jason Thieu	Michigan State A	CWRU D	131	10
Zac Stapler	Pittsburgh	Ohio State B	131	10
David Ropp	Duke A	William & Mary B	131	10
Kevin Nolan	NCSU B	Tusculum A	131	10
Brayden Whitlow	George Mason C	Stony Brook	131	10
Yiwei Jiang	NYU C	Lehigh B	131	10
Ben Spirtas	Maryland C	Lehigh A	131	10
John Shelly	Rowan	Columbia B	131	10
Sam Hewitt	WashU Grizzlers	Chicago B	131	10
Sam Alahi	Illinois Orange	Purdue C	131	10
Emily Justak	Indiana B	Chicago A	131	10
James Windle	Purdue D	Iowa B	131	10
Will Huang	Wisconsin A	Macalester	131	10
Ben Stras	Wisconsin C	Wisconsin B	131	0
Will Demos	Wisconsin B	Wisconsin C	131	10
Jack Granahan	Brandeis Mozart	Vermont B	131	10
Yvonne Pan	Amherst B	Dartmouth A	131	10
William Berger	Dartmouth C	MIT B	131	10
Cecile Thomas	Tufts A	UConn A	131	10
Christopher Bradley	Southern Connecticut State University A	Williams A	131	10
Logan Van Pelt	Washington Coho	Washington Chinook	131	10
Daniel Slater	Tennessee Tech	Auburn B	131	10
Caleb Slusher	South Carolina A	Georgia Tech A	131	10
Isabel Dent	Sewanne	Georgia Tech D	131	10
Ada Bendel	Bristol	Cardiff	131	10
Mata Cooper	Southampton	Cambridge A	131	10
Nicholas Hall	Cambridge E	Oxford	131	0
Nayaaz Hashim	Oxford	Cambridge E	131	10
David Latimer	Imperial A	Cambridge D	131	10
Jolie Yeh	Warwick	LSE	131	10
Gregory Stone	ESF	RIT B	131	0
Andres Lorenzo	RIT B	ESF	131	10

Summary

Tournament	Edition	TUH	Conv. %	Neg %	Average Buzz
UK (North)	UK	5	100%	0%	108.20
UK (South)	UK	8	100%	38%	126.88
Northern California	US	4	100%	75%	123.25
Southern California	US	7	100%	57%	116.43
Eastern Canada (1)	US	5	100%	20%	101.80
Eastern Canada (2)	US	9	100%	22%	114.11
Florida	US	4	100%	75%	123.25
Great Lakes	US	11	100%	27%	113.00
Lower Mid-Atlantic	US	9	100%	0%	113.11
Upper Mid-Atlantic	US	12	100%	33%	112.00
Midwest	US	9	100%	44%	117.22
North	US	4	100%	25%	114.50
Northeast	US	12	100%	25%	121.50
Pacific	US	8	100%	13%	117.25
Southeast	US	13	100%	23%	116.92
Upstate NY	US	5	100%	0%	112.00