mRNA - 2025 ACF Fall

Tossup

This molecule’s turnover occurs in phase-separated regions called P-bodies. The “alternative” form of one process produces around 38,000 (-5[1])different versions of this molecule from DSCAM (“D-S-cam”). This molecule’s IRES is typically located within one of its two (10[1])UTRs. This molecule’s precursor is processed (10[1]-5[1])by (10[1])a complex (10[1]-5[1])of (10[4])snRNPs (10[3])(“snurps”) called (10[2])a spliceosome, (10[7]-5[5])which (10[2])excises (-5[1])its (10[2])introns (10[6]-5[1])to form (10[3])this molecule. (10[8]-5[8])In eukaryotes, (10[1])this molecule (-5[1])is given a 5’ (10[1]-5[2])(“5-prime”) cap (10[3]-5[4])and a poly-A (10[3]-5[3])tail (-5[2])to prevent (10[3]-5[1])degradation. (10[1]-5[6])When synthesizing (10[1]-5[1])this molecule, (10[2])adenine (10[1]-5[2])on a template (-5[3])is paired with uracil (10[1]0[1])instead (-5[1])of thymine. (10[6]0[4])For (10[1])10 points, (10[1]-5[1])name this (0[1])single-stranded (10[1])molecule (10[3])produced by (10[1])transcribing (10[1])DNA. (10[2]0[1])■END■ (10[15]0[7])

ANSWER: mRNA [or messenger RNA or messenger ribonucleic acid; accept pre-mRNA or pre-messenger RNA or pre-messenger ribonucleic acid; prompt on RNA or ribonucleic acid] (The second line refers to alternative splicing.)

= Average correct buzz position

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Buzzes

Player	Team	Opponent	Position	Value
Brian Hobmann	UCLA F	Claremont B	17	-5
Jeremy Kim	Toronto F	Waterloo C	35	10
Yoyo Liu	British Columbia C	Boise State	41	10
Aiden Shields	Clemson A	Vanderbilt C	41	-5
Victor Xu	Toronto B	Waterloo A	42	10
Charlie Ruff	McGill A	Ottawa A	44	10
Tristan Scarlett	Ottawa D	Carleton B	44	-5
Aditya Koushik	Stanford B	Berkeley Archer Queen	45	10
Kevin Hendargo	UCSD A	UCLA B	45	10
Jason Thieu	Michigan State A	Ohio State A	45	10
Claire Wilson	Lehigh B	Rutgers B	45	10
Eric Morshed	Johns Hopkins	George Mason A	46	10
Xavier Bornhorst	Maryland A	NYU A	46	10
Matthew Westley	Purdue A	Illinois Orange	46	10
Fern Fang	VCU A	JMU A	47	10
Dustin Sanders	Chicago B	Chicago A	47	10
Hansen Jin	Berkeley Skeleton King	Berkeley Boss Bandit	49	10
Nick Machin	UCLA A	UC Irvine	49	10
Thomas Brittain	McMaster C	Toronto A	49	-5
Pratham Bhanushali	WVU B	Louisville D	49	-5
Pace Klein	CWRU B	Michigan A	49	10
Snehan Saroch	Louisville A	Michigan B	49	10
Reed Sexton	Michigan C	Ohio State B	49	-5
Nathan Woolery	Louisville C	Michigan State C	49	10
Johnathan Ahdout	Princeton	George Mason B	49	10
Austin Tran	Rose-Hulman A	Illinois Canada	49	10
Camden Walker	WashU Grolars	William Woods University A	49	-5
Ben Stras	Wisconsin C	Wisconsin B	49	-5
Samuel Li	William & Mary A	JMU B	50	10
Penelope Graham	Williams B	Dartmouth C	50	10
Arjun Saulnier	CWRU C	Pittsburgh	51	-5
Surya Donath	Stanford A	UCSC	52	10
Brendan Bridle	Queen's A	Toronto G	52	10
Aarav Kakad	UCLA C	Claremont A	53	10
Michael Xu	McMaster B	Toronto I	53	10
Alexandra Knight	Liberty B	Virginia A	53	10
Noah Fine	UNC D	NCSU A	53	-5
Mahathi Veluri	UConn A	Brandeis Beethoven	53	10
Ayaan Jajodia	Dartmouth B	Williams C	53	10
Jaime Wang	Washington Atlantic	Washington Chinook	53	10
Chen Nagahawatte	Ottawa B	McGill B	55	10
Joseph Strom	Louisville B	Ohio State C	55	10
Caleb Slusher	South Carolina A	Georgia Tech E	55	10
Jackson Crickard	Claremont B	UCLA F	57	10
Ethan Ririe	UCSD B	USC B	57	10
Christian Humeniuk	McMaster A	Toronto E	57	-5
Miles Phillips	Florida Tech B	UCF A	57	10
Nick Smemoe	UNC A	UNC C	57	-5
Cooper Morris	Columbia B	Maryland C	57	10
Sriram Koritala	Illinois Blue	Iowa B	57	10
Luke Sauer	Michigan Tech	St. Thomas	57	-5
Alice Zhang	Dartmouth A	Brown B	57	-5
Nathaniel Martin	Brandeis Bach	Tufts C	57	-5
Kyle Hart	MIT B	Vermont A	57	10
Suyog Vibhuti	Washington Steelhead	Washington Coho	57	-5
Brayden Zhang	Vanderbilt B	Auburn B	57	-5
Darren Kellis	Vanderbilt A	Georgia Tech C	57	10
Minh Nguyen	Cornell B	RIT A	57	-5
Connor Yu	Cornell C	RIT B	57	10
Alan Cai	Amherst A	Boston College B	59	10
Mohamed Algraiw	MIT A	Boston University B	61	-5
Yun Loh	Penn	Rutgers A	65	10
Jeremy Scurlock	Chipola College	Clemson B	65	-5
Eli O'Sick Johnson	Binghamton C	Binghamton B	65	-5
Ibraheem Alkrahgholy	Guelph A	Toronto H	66	10
Jun Chen	George Mason C	Rutgers C	66	-5
Andrew Wu	Columbia A	Rutgers D	66	-5
Ba Loc Dinh	Illinois Urbana	Indiana B	66	-5
Joanna Xiao	Georgia Tech B	Auburn C	66	-5
Gabrielle Smith	Auburn A	Georgia Tech D	66	10
Sammy Carstens	Rochester	Cornell A	66	10
Andrea Owusu	Duke A	Liberty A	69	-5
Audrey Nolan	NCSU B	Tusculum A	69	10
Beckett Pursey	Purdue B	Purdue D	69	10
Alex Smits	Wisconsin A	Minnesota	69	-5
Jonathan Ho	Alberta B	Washington State	69	10
Martin Brandenburg	Georgia A	Clemson C	69	-5
Nikola Wu	UCLA D	Claremont C	70	-5
Andrew Sklar	Vassar B	Vassar A	70	-5
Julia Marder	Pittsburgh	CWRU C	72	10
Grace Early	Iowa A	WashU Grizzlers	72	10
Reid Eichberg	Tufts B	Southern Connecticut State University A	72	10
Brendan Liaw	British Columbia A	British Columbia B	72	-5
Hermione Lu	Berkeley Little Prince	Berkeley Mighty Miner	73	-5
Winston Zuo	UC Santa Barbara	USC A	73	-5
June Miller	Florida A	ERAU Daytona A	73	-5
David Black	Illinois Champaign	Indiana A	73	-5
Beverly Eborn	Boston College A	Harvard	73	10
Yvonne Pan	Amherst B	Vermont B	73	-5
Peter Smith	Binghamton A	ESF	73	-5
Juan Landaeta	Florida State A	Florida B	75	10
Daniel Lu	Washington Pink	Arizona State A	75	-5
Sophia Jagels	William & Mary B	Liberty C	77	10
Edward Zhang	Vanderbilt C	Clemson A	77	10
Manobhiram Vegendla	Ohio State D	Michigan D	78	-5
Drew Wetterlind	Iowa State	Macalester	78	-5
Grace Lovitt	Washington Masu	Washington Chum	78	10
Kenner Bailey	Boston University A	Brown A	81	-5
Nivedh Mudiam	Arizona State B	Alberta A	81	-5
Towery McNeil	Mississippi State A	Emory A	81	-5
Emily Justak	Indiana B	Illinois Urbana	85	0
Ariyan Miah	Binghamton B	Binghamton C	85	10
Elena Yarrington	Michigan State D	WVU A	86	-5
Sarah Silverman	Claremont C	UCLA D	88	10
Chris Chang	USC A	UC Santa Barbara	88	10
Vedang Singhal	UNC C	UNC A	88	10
Alma Gazzaniga	UNC B	William & Mary C	88	10
Gavin Chen	Vassar A	Vassar B	88	0
Connor King	St. Thomas	Michigan Tech	88	0
Nico Miller	Brown B	Dartmouth A	88	10
Nikhil Nair	Boston University B	MIT A	88	0
Jackson McDonald	Alabama A	Tennessee B	88	10
Gregory Stone	ESF	Binghamton A	88	0
Isabel Dent	Sewanne	Montevallo	89	10
Ethen Sun	Toronto C	Brock A	91	10
Tinashe Sandy	South Florida A	Florida Tech A	91	-5
Brandon Hunt	Auburn B	Vanderbilt B	93	0
Joel Kim	Clemson B	Chipola College	94	10
Nathan Redford	Liberty A	Duke A	95	10
Devon Kumar	Tufts C	Brandeis Bach	95	10
Daniel Slater	Tennessee Tech	Georgia Tech F	95	10
Aryan Malhotra	Rutgers C	George Mason C	97	10
Apollo Daley	Brown A	Boston University A	98	10
Juan Morales Oropeza	Ottawa C	McGill C	99	10
Jesse Mindel	NCSU A	UNC D	99	0
Liam Markland	Alberta A	Arizona State B	99	10
Valerie Brown	Carleton B	Ottawa D	100	10
Sean Gao	Toronto E	McMaster A	100	0
James Xiao	Toronto A	McMaster C	100	10
Will Marcotte	Toronto D	Waterloo B	100	0
Ryan Gomes	Florida Tech A	South Florida A	100	0
Bonham Buchannon	Louisville D	WVU B	100	10
Joshua Lam	Ohio State B	Michigan C	100	10
Varun Ramanathan	Michigan D	Ohio State D	100	0
Alex Wong	Rutgers D	Columbia A	100	10
Trenton Burgess	Indiana A	Illinois Champaign	100	10
Alex Dzurick	William Woods University A	WashU Grolars	100	10
Ben Weng	Macalester	Iowa State	100	0
Alex Feller	Minnesota	Wisconsin A	100	10
Will Demos	Wisconsin B	Wisconsin C	100	10
Indigo Khanna	Vermont B	Amherst B	100	10
James O'Reilly	Arizona State A	Washington Pink	100	10
Joyann Hua	British Columbia B	British Columbia A	100	10
Lola Maas	Washington Coho	Washington Steelhead	100	0
Abby Tipton	Auburn C	Georgia Tech B	100	10
Andy Truette	Clemson C	Georgia A	100	0
Daniel Chen	Emory A	Mississippi State A	100	10
Danny Cutbill	RIT A	Cornell B	100	10

Summary

Tournament	Edition	TUH	Conv. %	Neg %	Average Buzz
Northern California	US	4	75%	25%	48.67
Southern California	US	7	100%	43%	62.43
Eastern Canada (1)	US	4	100%	25%	74.50
Eastern Canada (2)	US	9	78%	22%	62.71
Florida	US	4	50%	50%	66.00
Great Lakes	US	10	80%	50%	64.88
Lower Mid-Atlantic	US	9	89%	33%	70.88
Upper Mid-Atlantic	US	9	89%	33%	63.13
Midwest	US	9	89%	33%	67.50
North	US	4	50%	100%	100.00
Northeast	US	12	92%	42%	72.55
Pacific	US	8	88%	50%	77.14
Southeast	US	12	83%	50%	82.10
Upstate NY	US	5	80%	60%	77.00